There is either no or minimal gastric damage at doses of less than mg a day over three days. But, surprisingly, there is very little hard data to support that it can protect the stomach from NSAID damage.
Food does reduce stomach acid, from around battery acid levels to somewhere around that of tomato juice or black coffee. NSAIDs are better absorbed from acidic, rather than neutral, solutions. So an acidic stomach environment, after a night of fasting for instance, means NSAIDs will reach a higher blood concentration than after a meal.
In studies where animals were given high levels of NSAIDs after 24 to 48 hours of fasting, they developed ulcers in the stomach. On the other hand, animals that had been fed got ulcers in their intestine instead of their stomach.
That is, ulcers developed in both circumstances - they were just found in different locations. However, whether these effects are applicable to humans, especially with the typical doses used for pain relief, and whether different food components play a role in this shift from stomach to intestine ulceration, is unclear.
Pain relief is related to the concentrations of painkillers in the blood. Peak concentrations of ibuprofen in blood occur between 1.
For those who take it with just water, the maximum concentration is reached after 45 minutes. So taking ibuprofen with water is likely to result in better pain control and also reduce the need to take more. Having to take fewer doses in turn reduces the likelihood of gastrointestinal effects. Also, people who put off taking ibuprofen until they eat will suffer pain for longer than necessary.
This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs. Nonsteroidal anti-inflammatory drugs including ibuprofen may rarely increase the risk for a heart attack or stroke.
This effect can happen at any time while taking this drug but is more likely if you take it for a long time. The risk may be greater in older adults or if you have heart disease or increased risk for heart disease for example, due to smoking, family history of heart disease, or conditions such as high blood pressure or diabetes.
Do not take this drug right before or after heart bypass surgery CABG. Also, this drug may rarely cause serious rarely fatal bleeding from the stomach or intestines. This effect can occur without warning symptoms at any time while taking this drug. Older adults may be at higher risk for this effect. Talk with your doctor or pharmacist about the risks and benefits of treatment with this medication. Methocarbamol helps to relax the muscles.
Take this medication by mouth with or without food as directed by your doctor. Do not increase your dose or use this drug more often or for longer than prescribed.
Your condition will not improve any faster, and your risk of side effects will increase. Do not lie down for at least 10 minutes after taking this medication. If you have stomach upset while taking this medication, take it with food or milk. The dosage is based on your medical condition and response to treatment. To reduce your risk of stomach bleeding and other side effects, take this medication at the lowest effective dose for the shortest possible time.
If you are taking this drug "as needed" not on a regular schedule , remember that pain medications work best if they are used as the first signs of pain occur.
If you wait until the symptoms have worsened, the medicine may not work as well. Upset stomach, nausea, vomiting, heartburn, diarrhea, constipation, headache, dizziness, lightheadedness, or drowsiness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects.
Many people using this medication do not have serious side effects. This medication may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high.
This drug may rarely cause serious possibly fatal liver disease. Get medical help right away if you have any symptoms of liver damage, including:. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including:. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. Call your doctor for medical advice about side effects.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at Before taking this medication, tell your doctor or pharmacist if you are allergic to methocarbamol or ibuprofen; or to aspirin or other NSAIDs such as naproxen, celecoxib ; or if you have any other allergies.
This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of:. A protectant containing magnesium may help with faster relief. Gastrointestinal side effects are the most common problem reported with ibuprofen. Be sure to discuss your history of GI-related concerns with your healthcare provider before taking ibuprofen on your own.
In limited cases, for fast relief of pain symptoms, taking ibuprofen on an empty stomach may be fine. A magnesium -containing antacid may offer some protection and help provide faster relief. In some cases, your doctor will choose a different medication option. Learn about ibuprofen side effects here, including common ones, such as stomach…. NSAIDs may be the most commonly used medications around, but like any medication, they have side effects.
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